[HTML][HTML] High-content CRISPR screening
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …
interrogation of gene function in a wide range of applications and species. In pooled …
Liquid biopsy enters the clinic—implementation issues and future challenges
M Ignatiadis, GW Sledge, SS Jeffrey - Nature reviews Clinical oncology, 2021 - nature.com
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour
cells in peripheral blood have provided crucial insights into cancer biology and the …
cells in peripheral blood have provided crucial insights into cancer biology and the …
[HTML][HTML] N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression
Z Dai, H Liu, J Liao, C Huang, X Ren, W Zhu, S Zhu… - Molecular cell, 2021 - cell.com
Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …
cancer survival and progression, but the underlying mechanisms are poorly understood …
STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma
Metastasis frequently develops from disseminated cancer cells that remain dormant after the
apparently successful treatment of a primary tumour. These cells fluctuate between an …
apparently successful treatment of a primary tumour. These cells fluctuate between an …
[HTML][HTML] Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …
Ribosome biogenesis: a central player in cancer metastasis and therapeutic resistance
Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …
translation machines. Ribosome biogenesis is a multistep process that begins in the …
[HTML][HTML] Microfluidics-free single-cell genomics with templated emulsification
IC Clark, KM Fontanez, RH Meltzer, Y Xue… - Nature …, 2023 - nature.com
Current single-cell RNA-sequencing approaches have limitations that stem from the
microfluidic devices or fluid handling steps required for sample processing. We develop a …
microfluidic devices or fluid handling steps required for sample processing. We develop a …
Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota
Selenoprotein plays a crucial role in immune cells and inflammatory regulation. However, as
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …
a protein drug that is easily denatured or degraded in the acidic environment of the stomach …
Liquid biopsies: Potential and challenges
I Heidrich, L Ačkar… - … Journal of Cancer, 2021 - Wiley Online Library
The analysis of tumor cells or tumor cell products obtained from blood or other body fluids
(“liquid biopsy”[LB]) provides a broad range of opportunities in the field of oncology. Clinical …
(“liquid biopsy”[LB]) provides a broad range of opportunities in the field of oncology. Clinical …
Translational control of stem cell function
JA Saba, K Liakath-Ali, R Green, FM Watt - Nature reviews Molecular …, 2021 - nature.com
Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …
cell types. Research has focused primarily on how these processes are regulated at a …