Our understanding of Mycobacterium tuberculosis DNA repair mechanisms is still poor
compared with that of other bacterial organisms. However, the publication of the first …

Background The burden of drug resistant tuberculosis in Africa is largely driven by the
emergence and spread of multidrug resistant (MDR) and extensively drug resistant (XDR) …

Background. Ethambutol is used for the treatment of tuberculosis in cases where there is
isoniazid resistance. We examined the emergence of drug resistance to ethambutol …

Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic
infections in humans and, during the infectious process, are exposed to a range of …

Drug induced reversion of antibiotic resistance is a promising way to combat multidrug
resistant infections. However, lacking knowledge of mechanisms of drug resistance …

Nucleotide excision repair (NER) is one of the most extensively studied DNA repair
processes in both prokaryotes and eukaryotes. The NER pathway is a highly conserved …

Globally, specific genotypes of Mycobacterium tuberculosis have been shown to dominate in
patients, suggesting that these are more successful pathogens. One such genotype, the …

Tuberculosis (TB) incidence and mortality rates are still high in Sub-Saharan Africa, and the
knowledge about the current patterns is valuable for policymaking to decrease the TB …

Background: In Ethiopia, little has been done to assess how Mycobacterium bovis has
contributed to human tuberculosis, though the population routinely consumes unpasteurized …

Abstract Background Drug resistance in Mycobacterium tuberculosis (MTB) is one of the
major challenges in tuberculosis (TB) treatment. However, known mutations cannot explain …