Cytotoxic Potential of the Coelomic Fluid Extracted from the Sea Cucumber Holothuria tubulosa against Triple-Negative MDA-MB231 Breast Cancer Cells
C Luparello, D Ragona, DML Asaro, V Lazzara… - Biology, 2019 - mdpi.com
Growing evidence has demonstrated that the extracts of different holothurian species exert
beneficial effects on human health. Triple negative breast cancers (TNBC) are highly …
beneficial effects on human health. Triple negative breast cancers (TNBC) are highly …
Understanding the effect of structural diversity in WRKY transcription factors on DNA binding efficiency through molecular dynamics simulation
A precise understanding of the molecular mechanism involved in stress conditions has great
importance for crop improvement. Biomolecules, such as WRKY proteins, which are the …
importance for crop improvement. Biomolecules, such as WRKY proteins, which are the …
Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451
SD Hargrave, AM Joubert, BVL Potter, W Dohle… - Molecules, 2022 - mdpi.com
A tetrahydroisoquinoline (THIQ) core is able to mimic the A and B rings of 2-
methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising …
methoxyestradiol (2ME2), an endogenous estrogen metabolite that demonstrates promising …
Tetrahydroisoquinoline sulfamates as potent microtubule disruptors: Synthesis, antiproliferative and antitubulin activity of dichlorobenzyl-based derivatives, and a …
W Dohle, AE Prota, G Menchon, E Hamel… - ACS …, 2019 - ACS Publications
Tetrahydroisoquinoline (THIQ) 6-O-sulfamate-based anticancer agents, inspired by the
endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored …
endogenous steroid 2-methoxyestradiol and its sulfamate derivatives, are further explored …
Prostaglandins Isolated from the Octocoral Plexaura homomalla: In Silico and In Vitro Studies Against Different Enzymes of Cancer
DX Hurtado, FA Castellanos, E Coy-Barrera, E Tello - Marine drugs, 2020 - mdpi.com
Prostaglandin A2-AcMe (1) and Prostaglandin A2 (2) were isolated from the octocoral
Plexaura homomalla and three semisynthetic derivatives (3–5) were then obtained using a …
Plexaura homomalla and three semisynthetic derivatives (3–5) were then obtained using a …
Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro
EM Nolte, AM Joubert, L Lafanechère… - International Journal of …, 2023 - mdpi.com
Radiation resistance and radiation-related side effects warrant research into alternative
strategies in the application of this modality to cancer treatment. Designed in silico to …
strategies in the application of this modality to cancer treatment. Designed in silico to …
Nonsteroidal sulfamate derivatives as new therapeutic approaches for Neurofibromatosis 2 (NF2)
Y Shen, C Arellano-Garcia, RE Menjivar… - BMC Pharmacology and …, 2019 - Springer
Background Neurofibromatosis 1 and 2, although involving two different tumour suppressor
genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes …
genes (neurofibromin and merlin, respectively), are both cancer predisposition syndromes …
The crystal structure of 6-amino-2-methyl-8-(4-(methylthio)phenyl)-2,3,8,8a-tetrahydroisoquinoline-5,7,7(1H)-tricarbonitrile – ethanol (1/1), C20H19N5S
D Li, H Zhang, Q Zhang, Y Zhou… - … für Kristallographie-New …, 2019 - degruyter.com
The crystal structure of 6-amino-2-methyl-8-(4-(methylthio)phenyl)-2,3, 8,8a-tetrahydroisoquinoline-5,7,7(1H)-tricarbonitrile
Page 1 Z. Kristallogr. NCS 2019; 234(2): 197–198 Da Li, Hua Zhang, Qing Zhang, Yan …
Page 1 Z. Kristallogr. NCS 2019; 234(2): 197–198 Da Li, Hua Zhang, Qing Zhang, Yan …