Actin participates in several essential processes in the cell nucleus. Even though the
presence of actin in the nucleus was proposed more than 30 years ago, nuclear processes …

Soft tissue sarcomas (STSs) are an uncommon group of solid tumors that can arise
throughout the human lifespan. Despite their commonality as non-bony cancers that develop …

Chromatin remodeling and histone modifications facilitate access of transcription factors to
DNA by promoting the unwinding and destabilization of histone–DNA interactions. We …

Loss of TGFBI, a secreted protein induced by transforming growth factor-β, has been
implicated in cell proliferation, tumor progression, and angiogenesis by in vitro studies …

MyoD is a master regulator of the skeletal muscle gene expression program. ChIP-Seq
analysis has recently revealed that MyoD binds to a large number of genomic loci in …

The eukaryotic genetic material is packaged in the form of chromatin by wrapping DNA
around nucleosomes. Cells maintain chromatin in a dynamic state by utilising various ATP …

Histone lysine (K) residues, which are modified by methyl-and acetyl-transferases, diversely
regulate RNA synthesis. Unlike the ubiquitously activating effect of histone K acetylation, the …

Transcriptional co-activators, co-repressors and chromatin remodeling machines are
essential elements in the transcriptional programs directed by the master adipogenic …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma accounting for 5–8% of
malignant tumours in children and adolescents. Children with high risk disease have poor …

Oligonucleotide-mediated splicing modulation is a promising therapeutic approach for
Duchenne muscular dystrophy (DMD). Recently, eteplirsen, a phosphorodiamidate …