Vitreous and vision degrading myodesopsia

J Sebag - Progress in Retinal and Eye Research, 2020 - Elsevier
Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state,
transparency, and physiologic function (s) within the eye. Myopia and aging alter collagen …

[HTML][HTML] Vitreous antioxidants, degeneration, and vitreo-retinopathy: exploring the links

E Ankamah, J Sebag, E Ng, JM Nolan - Antioxidants, 2019 - mdpi.com
The transparent vitreous body, which occupies about 80% of the eye's volume, is laden with
numerous enzymatic and non-enzymatic antioxidants that could protect the eye from …

Laser-induced nanobubbles safely ablate vitreous opacities in vivo

F Sauvage, VP Nguyen, Y Li, A Harizaj, J Sebag… - Nature …, 2022 - nature.com
In myopia, diabetes and ageing, fibrous vitreous liquefaction and degeneration is associated
with the formation of opacities inside the vitreous body that cast shadows on the retina …

[HTML][HTML] Rheological properties and age-related changes of the human vitreous humor

NK Tram, KE Swindle-Reilly - Frontiers in bioengineering and …, 2018 - frontiersin.org
The vitreous humor is a fragile, transparent hydrogel situated between the lens and the
retina, occupying 80% of the eye's volume. Due to its viscoelastic behavior, the vitreous …

[HTML][HTML] Rheological behaviour of vitreous humour

AF Silva, MA Alves, MSN Oliveira - Rheologica Acta, 2017 - Springer
The vitreous humour (VH) is a complex biofluid that occupies a large portion of the eyeball
between the lens and the retina, and exhibits non-Newtonian rheological properties that are …

[HTML][HTML] A bioinspired gelatin-hyaluronic acid-based hybrid interpenetrating network for the enhancement of retinal ganglion cells replacement therapy

PC Dromel, D Singh, E Andres, M Likes… - NPJ Regenerative …, 2021 - nature.com
Biomaterial-based cell replacement approaches to regenerative medicine are emerging as
promising treatments for a wide array of profound clinical problems. Here we report an …

[HTML][HTML] Importance of the use of oxidative stress biomarkers and inflammatory profile in aqueous and vitreous humor in diabetic retinopathy

AK López-Contreras, MG Martínez-Ruiz… - Antioxidants, 2020 - mdpi.com
Diabetic retinopathy is one of the leading causes of visual impairment and morbidity
worldwide, being the number one cause of blindness in people between 27 and 75 years …

Hyaluronan as a promising excipient for ocular drug delivery

M Guter, M Breunig - European journal of pharmaceutics and …, 2017 - Elsevier
Hyaluronan (HA) is a naturally occurring polysaccharide and well known for its exceptional
properties such as high biocompatibility and biodegradability, along with a low …

[HTML][HTML] The effect of light sensitizer localization on the stability of indocyanine green liposomes

T Lajunen, R Nurmi, D Wilbie, T Ruoslahti… - Journal of Controlled …, 2018 - Elsevier
Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy,
providing both temporal and spatial control of drug release. We have developed light …

[HTML][HTML] Diffusion through the ex vivo vitreal body–bovine, porcine, and ovine models are poor surrogates for the human vitreous

S Shafaie, V Hutter, MB Brown, MT Cook… - International journal of …, 2018 - Elsevier
The human vitreous humour is a complex gel structure whose composition and physical
properties can vary considerably from person to person and also change with age. To date …