Normal human pregnancy is considered a state of enhanced oxidative stress. In pregnancy,
it plays important roles in embryo development, implantation, placental development and …

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

Diabesity is an abnormal metabolic condition shown by patients with obesity that develop
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …

Objective—Gestational diabetes mellitus (GDM) produces fetal hyperglycemia with
increased lifelong risks for the exposed offspring of cardiovascular and other diseases …

The pancreas is an organ with a central role in nutrient breakdown, nutrient sensing and
release of hormones regulating whole body nutrient homeostasis. In diabetes mellitus, the …

Human endothelial dysfunction is a common feature in many diseases of pregnancy, such
as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide …

OBJECTIVE To determine whether insulin reverses gestational diabetes mellitus (GDM)–
reduced expression and activity of human equilibrative nucleoside transporters 1 (hENT1) in …

Gestational diabetes mellitus (GDM) and obesity in pregnancy (OP) are pathological
conditions associated with placenta vascular dysfunction coursing with metabolic changes …

Please cite this paper as: Leach (2011). Placental Vascular Dysfunction in Diabetic
Pregnancies: Intimations of Fetal Cardiovascular Disease? Microcirculation 18 (4), 263–269 …

Background: In spite of improvement in obstetrical care, pregnancy in women with type 1
diabetes mellitus is associated with increased perinatal morbidity and mortality …