Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health
BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …
information from both parents to the offspring. There is now compelling evidence that the …
Establishing, maintaining and modifying DNA methylation patterns in plants and animals
JA Law, SE Jacobsen - Nature Reviews Genetics, 2010 - nature.com
Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological
processes, including gene and transposon silencing, imprinting and X chromosome …
processes, including gene and transposon silencing, imprinting and X chromosome …
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation
K Xu, Y Yang, GH Feng, BF Sun, JQ Chen, YF Li… - Cell research, 2017 - nature.com
METTL3 catalyzes the formation of N 6-methyl-adenosine (m 6 A) which has important roles
in regulating various biological processes. However, the in vivo function of Mettl3 remains …
in regulating various biological processes. However, the in vivo function of Mettl3 remains …
[HTML][HTML] Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing
the current number of known histone marks by about 70%. We further investigated one of the …
the current number of known histone marks by about 70%. We further investigated one of the …
Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes
Epidemiological studies suggest that a father's diet can influence offspring health. A
proposed mechanism for paternal transmission of environmental information is via the …
proposed mechanism for paternal transmission of environmental information is via the …
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …
throughput profiling of histone modifications in mammalian cells. By obtaining over four …
Lysine benzoylation is a histone mark regulated by SIRT2
H Huang, D Zhang, Y Wang, M Perez-Neut… - Nature …, 2018 - nature.com
Metabolic regulation of histone marks is associated with diverse biological processes
through dynamically modulating chromatin structure and functions. Here we report the …
through dynamically modulating chromatin structure and functions. Here we report the …
Child health, developmental plasticity, and epigenetic programming
Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …
survival and reproductive success to the organism under changing environments …
De novo DNA methylation: a germ cell perspective
SA Smallwood, G Kelsey - Trends in Genetics, 2012 - cell.com
DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …
genome that has widespread influences on gene expression. During germ-cell specification …
In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
S Quenneville, G Verde, A Corsinotti, A Kapopoulou… - Molecular cell, 2011 - cell.com
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …