Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant
tumours that can arise at any point of the biliary tree. Their incidence is increasing globally …

The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Background and Aims Activation of the antitumor immune response using programmed
death receptor‐1 (PD‐1) blockade showed benefit only in a fraction of patients with …

Cholangiocarcinoma (CCA) is a heterogeneous group of malignancies with features of
biliary tract differentiation. CCA is the second most common primary liver tumour and the …

Cholangiocarcinoma represents a diverse group of epithelial cancers united by late
diagnosis and poor outcomes. Specific diagnostic and therapeutic approaches are …

Some types of circular RNA (circRNA) are aberrantly expressed in human diseases
including hepatocellular carcinoma (HCC). However, its regulation mechanism and …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

LGR4/5 receptors and their cognate RSPO ligands potentiate Wnt/β-catenin signalling and
promote proliferation and tissue homeostasis in epithelial stem cell compartments. In the …