Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of
cancer-related death. The high mortality rate results from a lack of methods for early …

INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …

The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and
metastasis. EMT is thought to be regulated primarily at the transcriptional level through the …

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

Simple Summary The cancer cells in solid tumors are embedded in a complex connective
tissue matrix composed of various other cell types, ie, mesenchymal stroma/stem-like cells …