Broadening the impact of immunotherapy to pancreatic cancer: challenges and opportunities
VP Balachandran, GL Beatty, SK Dougan - Gastroenterology, 2019 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second deadliest
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …
cancer in the United States by 2025, with 5-year survival at less than 10%. In other …
Employing metabolism to improve the diagnosis and treatment of pancreatic cancer
CJ Halbrook, CA Lyssiotis - Cancer cell, 2017 - cell.com
Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of
cancer-related death. The high mortality rate results from a lack of methods for early …
cancer-related death. The high mortality rate results from a lack of methods for early …
Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis
INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …
clinical observation. Although many studies have demonstrated that the inflammatory …
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
EMT subtype influences epithelial plasticity and mode of cell migration
Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and
metastasis. EMT is thought to be regulated primarily at the transcriptional level through the …
metastasis. EMT is thought to be regulated primarily at the transcriptional level through the …
Acinar cell plasticity and development of pancreatic ductal adenocarcinoma
P Storz - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …
[HTML][HTML] Cancer stem cells in immunoregulation and bypassing anti-checkpoint therapy
E Rouzbahani, J Majidpoor, S Najafi… - Biomedicine & …, 2022 - Elsevier
Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …
Pancreatic β cell regeneration as a possible therapy for diabetes
C Aguayo-Mazzucato, S Bonner-Weir - Cell metabolism, 2018 - cell.com
Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …
Emerging routes to the generation of functional β-cells for diabetes mellitus cell therapy
Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …
Impact of the tumor microenvironment on tumor heterogeneity and consequences for cancer cell plasticity and stemness
R Hass, J von der Ohe, H Ungefroren - Cancers, 2020 - mdpi.com
Simple Summary The cancer cells in solid tumors are embedded in a complex connective
tissue matrix composed of various other cell types, ie, mesenchymal stroma/stem-like cells …
tissue matrix composed of various other cell types, ie, mesenchymal stroma/stem-like cells …