The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Shedding light on the cell biology of extracellular vesicles

G Van Niel, G d'Angelo, G Raposo - Nature reviews Molecular cell …, 2018 - nature.com
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures
comprising exosomes and microvesicles, which originate from the endosomal system or …

[HTML][HTML] ALIX-and ESCRT-III–dependent sorting of tetraspanins to exosomes

J Larios, V Mercier, A Roux, J Gruenberg - Journal of Cell Biology, 2020 - rupress.org
The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling
receptors and other proteins to lysosomes for degradation, but they also modulate …

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

N Karimi, A Cvjetkovic, SC Jang, R Crescitelli… - Cellular and molecular …, 2018 - Springer
The isolation of extracellular vesicles (EVs) from blood is of great importance to understand
the biological role of circulating EVs and to develop EVs as biomarkers of disease. Due to …

Opportunities and challenges in studying the extracellular vesicle corona

EI Buzas - Nature Cell Biology, 2022 - nature.com
The extracellular vesicle (EV) surface corona is emerging as a crucial mediator of EV
functions. This Comment discusses the roles and biogenesis of the EV corona, as well as …

Biogenesis and function of ESCRT-dependent extracellular vesicles

T Juan, M Fürthauer - Seminars in cell & developmental biology, 2018 - Elsevier
From bacteria to humans, cells secrete a large variety of membrane-bound extracellular
vesicles. Only relatively recently has it however started to become clear that the exovesicular …

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

BW Sódar, Á Kittel, K Pálóczi, KV Vukman… - Scientific reports, 2016 - nature.com
Circulating extracellular vesicles have emerged as potential new biomarkers in a wide
variety of diseases. Despite the increasing interest, their isolation and purification from body …

Molecular interactions at the surface of extracellular vesicles

EI Buzás, EÁ Tóth, BW Sódar… - Seminars in …, 2018 - Springer
Extracellular vesicles such as exosomes, microvesicles, apoptotic bodies, and large
oncosomes have been shown to participate in a wide variety of biological processes and are …

CryoET of β-amyloid and tau within postmortem Alzheimer's disease brain

MAG Gilbert, N Fatima, J Jenkins, TJ O'Sullivan… - Nature, 2024 - nature.com
A defining pathological feature of most neurodegenerative diseases is the assembly of
proteins into amyloid that form disease-specific structures. In Alzheimer's disease, this is …