Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

Pesticides are important chemicals or biological agents that deter or kill pests. The use of
pesticides has continued to increase as it is still considered the most effective method to …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The transcription factor Nrf2 (NF-E2-related factor 2) plays a vital role in maintaining cellular
homeostasis, especially upon the exposure of cells to chemical or oxidative stress, through …

Reactive oxygen species (ROS) are continuously produced and eliminated by living
organisms normally maintaining ROS at certain steady-state levels. Under some …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is
repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently …

Quercetin, kaempferol, and pterostilbene are abundant in berries. The anti-oxidative
properties of these constituents may contribute to cancer chemoprevention. However, their …

The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox
homeostasis by controlling the expression of many endogenous antioxidants and phase II …