Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact

M MacLeod, A Papi, M Contoli, B Beghé, BR Celli… - …, 2021 - Wiley Online Library
In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized
by an acute deterioration in respiratory symptoms, are fundamental events impacting …

Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

PJ Barnes - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation
affecting predominantly the lung parenchyma and peripheral airways that results in largely …

An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal

BR Celli, LM Fabbri, SD Aaron, A Agusti… - American journal of …, 2021 - atsjournals.org
Over 200 years ago, René Laennec published the first description of emphysema, an
important pathobiological element of what is today known as chronic obstructive pulmonary …

Cellular and molecular mechanisms of asthma and COPD

PJ Barnes - Clinical science, 2017 - portlandpress.com
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …

Defining the relationship between COPD and CVD: what are the implications for clinical practice?

AD Morgan, R Zakeri, JK Quint - Therapeutic advances in …, 2018 - journals.sagepub.com
Cardiovascular diseases (CVDs) are arguably the most important comorbidities in chronic
obstructive pulmonary disease (COPD). CVDs are common in people with COPD, and their …

An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease

F Maltais, M Decramer, R Casaburi… - American journal of …, 2014 - atsjournals.org
Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

C-reactive protein testing to guide antibiotic prescribing for COPD exacerbations

CC Butler, D Gillespie, P White, J Bates… - … England Journal of …, 2019 - Mass Medical Soc
Background Point-of-care testing of C-reactive protein (CRP) may be a way to reduce
unnecessary use of antibiotics without harming patients who have acute exacerbations of …

Cellular and molecular mechanisms of chronic obstructive pulmonary disease

PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

Personalized protein corona on nanoparticles and its clinical implications

C Corbo, R Molinaro, M Tabatabaei… - Biomaterials …, 2017 - pubs.rsc.org
It is now well understood that once in contact with biological fluids, nanoscale objects lose
their original identity and acquire a new biological character, referred to as a protein corona …

Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers

M Bafadhel, S McKenna, S Terry, V Mistry… - American journal of …, 2011 - atsjournals.org
Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are
heterogeneous with respect to inflammation and etiology. Objectives: Investigate biomarker …