The “old” and the “new” antibiotics for MDR gram-negative pathogens: for whom, when, and how
The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …
significant challenges in the treatment of healthcare associated infections. An important …
What's new in multidrug-resistant pathogens in the ICU?
G Zilahi, A Artigas, I Martin-Loeches - Annals of intensive care, 2016 - Springer
Over the last several decades, antibacterial drug use has become widespread with their
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …
Individualising therapy to minimize bacterial multidrug resistance
The scourge of antibiotic resistance threatens modern healthcare delivery. A contributing
factor to this significant issue may be antibiotic dosing, whereby standard antibiotic regimens …
factor to this significant issue may be antibiotic dosing, whereby standard antibiotic regimens …
Amikacin in critically ill patients: a review of population pharmacokinetic studies
A Marsot, R Guilhaumou, C Riff, O Blin - Clinical pharmacokinetics, 2017 - Springer
Background Amikacin is an aminoglycoside commonly used in intensive care units for the
treatment of patients with life-threatening Gram-negative infections. Although …
treatment of patients with life-threatening Gram-negative infections. Although …
Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility
AP Zavascki, BO Klee, JB Bulitta - Expert review of anti-infective …, 2017 - Taylor & Francis
Introduction: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has
brought aminoglycosides to the frontline since an aminoglycoside may be the only …
brought aminoglycosides to the frontline since an aminoglycoside may be the only …
Evaluation of amikacin pharmacokinetics and pharmacodynamics for optimal initial dosing regimen
H Kato, M Hagihara, J Hirai, D Sakanashi, H Suematsu… - Drugs in R&D, 2017 - Springer
Amikacin has been one of the important antimicrobial agents against Gram-negative
pathogens. However, there is discrepancy regarding the amikacin initial dosage, with some …
pathogens. However, there is discrepancy regarding the amikacin initial dosage, with some …
Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation
C Touchard, A Aubry, P Eloy, N Bréchot, G Lebreton… - Critical Care, 2018 - Springer
Background Amikacin infusion requires targeting a peak serum concentration (C max) 8–10
times the minimal inhibitory concentration, corresponding to a C max of 60–80 mg/L for the …
times the minimal inhibitory concentration, corresponding to a C max of 60–80 mg/L for the …
Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?
Purpose Vancomycin is commonly used for the management of severe infections; however,
vancomycin dosing may be challenging in critically ill patients. This observational study aims …
vancomycin dosing may be challenging in critically ill patients. This observational study aims …
Biofilm infections between Scylla and Charybdis: interplay of host antimicrobial peptides and antibiotics
S Chernysh, N Gordya, D Tulin… - Infection and drug …, 2018 - Taylor & Francis
Purpose: The aim of this study is to improve the anti-biofilm activity of antibiotics. We
hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can …
hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can …
Optimizing the initial amikacin dosage in adults
We report on the pharmacokinetics (PK) and pharmacodynamics (PD) of high-dose (> 15
mg/kg of body weight per day) amikacin. A mean (standard deviation [SD]) maximum drug …
mg/kg of body weight per day) amikacin. A mean (standard deviation [SD]) maximum drug …