Applications and limitations of dendrimers in biomedicine

AA Chis, C Dobrea, C Morgovan, AM Arseniu, LL Rus… - Molecules, 2020 - mdpi.com
Biomedicine represents one of the main study areas for dendrimers, which have proven to
be valuable both in diagnostics and therapy, due to their capacity for improving solubility …

Drug nanocrystals: Fabrication methods and promising therapeutic applications

IS Mohammad, H Hu, L Yin, W He - International journal of pharmaceutics, 2019 - Elsevier
The drug nanocrystals (NCs) with unique physicochemical properties are now considered
as a promising drug delivery system for poorly water-soluble drugs. So far> 20 formulations …

Fabrication of tri-layered electrospun polycaprolactone mats with improved sustained drug release profile

SM Kamath, K Sridhar, D Jaison, V Gopinath… - Scientific Reports, 2020 - nature.com
Modulation of initial burst and long term release from electrospun fibrous mats can be
achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous …

Assessing the drug delivery of ibuprofen by the assistance of metal-doped graphenes: insights from density functional theory

S Esfahani, J Akbari, S Soleimani-Amiri… - Diamond and Related …, 2023 - Elsevier
Quantum chemical density functional theory (DFT) calculations were performed to examine
features of metal-doped graphene (MG) models for adsorbing the popular ibuprofen (IBU) …

Clinical practice guideline: opioid prescribing for analgesia after common otolaryngology operations

S Anne, JW Mims, DE Tunkel… - … –Head and Neck …, 2021 - Wiley Online Library
Objective Opioid use disorder (OUD), which includes the morbidity of dependence and
mortality of overdose, has reached epidemic proportions in the United States …

Enhancement of ibuprofen solubility and skin permeation by conjugation with L-valine alkyl esters

E Janus, P Ossowicz, J Klebeko, A Nowak… - RSC …, 2020 - pubs.rsc.org
New ibuprofen derivatives were made via conjugation with L-valine alkyl esters (ValOR),
where R was changed from an ethyl to a hexyl group. The ionic structure was confirmed …

Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics

A Ćirić, Đ Medarević, B Čalija, V Dobričić… - International journal of …, 2020 - Elsevier
This study investigated the combined influence of pH adjusting agent type (hydrochloric,
acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible …

Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: a network meta-analysis

W Nie, P Xu, C Hao, Y Chen, Y Yin, L Wang - Medicine, 2020 - journals.lww.com
Background: Primary dysmenorrhea is common and troublesome. The comparative efficacy
of over-the-counter analgesics (OTCAs) for dysmenorrhea is unclear. This study was aimed …

Predicting the formation of NADES using a transformer-based model

LB Ayres, FJV Gomez, MF Silva, JR Linton… - Scientific Reports, 2024 - nature.com
The application of natural deep eutectic solvents (NADES) in the pharmaceutical,
agricultural, and food industries represents one of the fastest growing fields of green …

Parenteral ready-to-use fixed-dose combinations including NSAIDs with paracetamol or metamizole for multimodal analgesia—approved products and challenges

F Silva, G Costa, F Veiga, C Cardoso… - Pharmaceuticals, 2023 - mdpi.com
The combination of non-steroidal anti-inflammatory drugs (NSAIDs) with non-opioid
analgesics is common in clinical practice for the treatment of acute painful conditions like …