Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

During collective migration of epithelial cells, the migration direction is aligned over a tissue-
scale expanse. Although the collective cell migration is known to be directed by mechanical …

Smooth muscle cell migration has been implicated in the development of respiratory and
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …

Platelet aggregation at sites of vascular injury is essential for hemostasis but also
thrombosis. Platelet adhesiveness is critically dependent on agonist-induced inside-out …

Glioblastoma is the most aggressive and invasive brain tumor and has a poor prognosis;
elucidating the underlying molecular mechanisms is essential to select molecular targeted …

Vascular smooth muscle cells (VSMCs) are thought to assume a quiescent and
homogeneous mechanical behavior after arterial tree development phase. However …

Human clear cell renal cell carcinoma (ccRCC) is therapy resistant; therefore, it is
worthwhile studying in depth the molecular aspects of its progression. In ccRCC the biallelic …

Phosphoinositides are a group of lipids that regulate intracellular signaling and subcellular
biological events. The signaling by phosphatidylinositol-3, 4, 5-trisphosphate and Akt …