[HTML][HTML] Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes

S Akter, KS Chauhan, MD Dunlap, JA Choreño-Parra… - Cell reports, 2022 - cell.com
Summary Mycobacterium tuberculosis (Mtb) infects 25% of the world's population and
causes tuberculosis (TB), which is a leading cause of death globally. A clear understanding …

[HTML][HTML] The Detection of Mutations and Genotyping of Drug-Resistant Mycobacterium tuberculosis Strains Isolated from Patients in the Rural Eastern Cape Province

LM Faye, MC Hosu, S Oostvogels, A Dippenaar… - Infectious disease …, 2023 - mdpi.com
Drug-resistant tuberculosis (DR-TB) is still a major public health concern in South Africa.
Mutations in M. tuberculosis can cause varying levels of phenotypic resistance to anti-TB …

[HTML][HTML] In-depth systems biological evaluation of bovine alveolar macrophages suggests novel insights into molecular mechanisms underlying Mycobacterium bovis …

A Hasankhani, A Bahrami, S Mackie… - Frontiers in …, 2022 - frontiersin.org
Objective Bovine tuberculosis (bTB) is a chronic respiratory infectious disease of domestic
livestock caused by intracellular Mycobacterium bovis infection, which causes~ $3 billion in …

[HTML][HTML] Effect of IL-17A on the immune response to pulmonary tuberculosis induced by high- and low-virulence strains of Mycobacterium bovis

Y Rodríguez-Míguez, V Lozano-Ordaz… - Plos one, 2024 - journals.plos.org
Tuberculosis (TB) is an infectious, chronic, and progressive disease occurring globally.
Human TB is caused mainly by Mycobacterium tuberculosis (M. tuberculosis), while the …

Do B-1 cells play a role in response to Mycobacterium tuberculosis Beijing lineages?

F Acosta, PL Fernández, A Goodridge - Virulence, 2022 - Taylor & Francis
We highlight the need to include an analysis of the B-1 B cell subset to complement the
characterization of the cell-mediated immune response to the Mycobacterium tuberculosis …

[HTML][HTML] Clinical isolates of Mycobacterium tuberculosis with different genotypes exhibit distinct host macrophage responses in vitro

C Liang, X Li, Q Li, X Zhang, W Ren… - Journal of Medical …, 2022 - microbiologyresearch.org
Introduction. Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis, can
survive as an intracellular parasite after entering macrophages via phagocytosis. M. tb …

[HTML][HTML] Close Related Drug-Resistance Beijing Isolates of Mycobacterium tuberculosis Reveal a Different Transcriptomic Signature in a Murine Disease Progression …

MI Cerezo-Cortés, JG Rodríguez-Castillo… - International Journal of …, 2022 - mdpi.com
Mycobacterium tuberculosis (MTB) lineage 2/Beijing is associated with high virulence and
drug resistance worldwide. In Colombia, the Beijing genotype has circulated since 1997 …

[HTML][HTML] Bifurcation analysis of a tuberculosis progression model for drug target identification

E Flores-Garza, R Hernández-Pando… - Scientific Reports, 2023 - nature.com
Tuberculosis (TB) is a major cause of morbidity and mortality worldwide. The emergence
and rapid spread of drug-resistant M. tuberculosis strains urge us to develop novel …

Backtranslation of human RNA biosignatures of tuberculosis disease risk into the preclinical pipeline is condition dependent

H Painter, SE Larsen, BD Williams, HFM Abdelaal… - bioRxiv, 2024 - biorxiv.org
It is not clear whether human progression to active tuberculosis disease (TB) risk signatures
are viable endpoint criteria for evaluations of treatments in clinical or preclinical …

[HTML][HTML] Multidrug-Resistant Tuberculosis—Diagnostic Procedures and Treatment of Two Beijing-like TB Cases

M Kozińska, M Skowroński, P Gruszczyński… - Diagnostics, 2022 - mdpi.com
The Beijing/W genotype is one of the major molecular families of Mycobacterium
tuberculosis complex (MTBC), responsible for approximately 50% of tuberculosis (TB) cases …