The acquisition of genomic instability is one of the key characteristics of the cancer cell, and
microsatellite instability (MSI) is an important segment of this phenomenon. This review aims …

During the last decade, it has become clear that aberrant microRNA expression has a
functional role in the initiation and progression of colorectal cancer (CRC). Specific …

Abstract Yes-associated protein 1 (YAP1) exerts significant effects in various malignancies.
However, the oncogenic role of YAP1 remains controversial, and the mechanism by which …

Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Dysregulation of microRNAs has a critical role in cancer progression. Here we identify an
intronic microRNA, miR-135b that is upregulated in highly invasive non-small-cell lung …

Genomic instability consists of a range of genetic alterations within the genome that
contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic …

Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently,
no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …

Cancer initiation and progression are defined by the behavior of cancer cells per se and the
development of tumor tissues, both of which are modulated by crosstalk between cancer …