Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in cftr, a gene encoding a
PKA-regulated Cl− channel. The most common mutation results in a deletion of …

The pathways that distinguish transport of folded and misfolded cargo through the exocytic
(secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global …

Tissue-specific extracellular matrices (ECMs) are crucial for normal development and tissue
function, and mutations in ECM genes result in a wide range of serious inherited connective …

Loss-of-function diseases are often caused by a mutation in a protein traversing the
secretory pathway that compromises the normal balance between protein folding, trafficking …

The endoplasmic reticulum (ER) is the site of folding for proteins that are resident in the ER
or that are destined for the Golgi, endosomes, lysosomes, the plasma membrane, or …

Following sequencing and assembly of the human genome, the preferred methods for
identification of new drug targets have changed dramatically. Modern tactics such as …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

The identification, characterization, and mutational analysis of three different genes—the
arginine vasopressin gene (AVP), the arginine vasopressin receptor 2 gene (AVPR2), and …