Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion
among primary brain tumors is highest in children and young adults. Thus, the level of …

The sphingomyelin (SM) cycle is an emerging pathway of signal transduction that plays a
role in the control of cell growth, cell differentiation, and apoptosis. During earlier …

Background Therapy for ependymoma includes aggressive surgical intervention and
radiotherapy administered by use of methods that keep the risk of side-effects to a minimum …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …

Purpose We conducted a phase II trial of conformal radiation therapy (CRT) for localized
childhood ependymoma to determine whether the irradiated volume could be reduced to …

Background This prospective study stratified patients by surgical resection (complete= NED
vs incomplete= ED) and centrally reviewed histology (World Health Organization [WHO] …

Purpose To delineate clinically relevant molecular signatures of intracranial ependymoma.
Materials and Methods We analyzed 24 primary intracranial ependymomas. For genomic …

Background Relapse occurs in 50% of pediatric ependymoma cases and has poor
prognosis. Few studies have investigated the clinical progress of relapsed disease, and …

Response criteria for paediatric intracranial ependymoma vary historically and across
different international cooperative groups. The Response Assessment in the Pediatric Neuro …

Purpose: The high incidence of recurrence and unpredictable clinical outcome for pediatric
ependymoma reflect the imprecision of current therapeutic staging and need for novel risk …