Background Physical activity may attenuate age-related cognitive decline by improving
cerebrovascular function. The aim of this study was therefore to investigate effects of aerobic …

Adequate cerebral blood flow (CBF) is essential to a healthy central nervous system (CNS).
Previous work suggests that CBF differs between men and women, and declines with age …

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) has become a popular
approach for studying cerebral hemodynamics in a range of disorders and has recently …

Cerebral blood flow (CBF) decreases across the adult lifespan; however, more studies are
needed to understand the underlying mechanisms. This study measured CBF and …

Accumulating evidence suggests vascular dysregulation in preclinical Alzheimer's disease.
In this study, cerebral hemodynamics and their coupling with cognition in middle-aged …

Objectives: Aging is a major risk factor for many neurological disorders and is associated
with dural lymphatic dysfunction. We sought to evaluate the association of aging with the …

Cerebral small vessel disease (SVD) is common in older people and is associated with
lacunar stroke, white matter hyperintensities (WMH) and vascular cognitive impairment …

Ageing causes extensive structural changes to the human cerebral microvasculature, which
have a significant effect on capillary bed perfusion and oxygen transport. Current models of …

Introduction Loss of blood-brain barrier (BBB) integrity is hypothesised to be one of the
earliest microvascular signs of Alzheimer's disease (AD). Existing BBB integrity imaging …

While the associations of mid-life cardiovascular risk factors with late-life white matter
lesions (WMH) and cognitive decline have been established, the role of cerebral …