Recent advances in mass spectrometry-based computational metabolomics

TMD Ebbels, JJJ van der Hooft, H Chatelaine… - Current opinion in …, 2023 - Elsevier
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …

Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids

R Mirzaei, B Kavyani, E Nabizadeh, H Kadkhoda… - Heliyon, 2023 - cell.com
Several disorders have been linked to modifications in the gut microbial imbalance,
intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain …

[HTML][HTML] Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis

Y Sun, H Tang, S Du, Y Chen, Z Ou, M Zhang… - Eco-Environment & …, 2023 - Elsevier
Indoor microorganisms impact asthma and allergic rhinitis (AR), but the associated microbial
taxa often vary extensively due to climate and geographical variations. To provide more …

Metabolomics and lipidomics strategies in modern drug discovery and development

G Astarita, RS Kelly, J Lasky-Su - Drug Discovery Today, 2023 - Elsevier
Metabolomics and lipidomics have an increasingly pivotal role in drug discovery and
development. In the context of drug discovery, monitoring changes in the levels or …

Relationship between human papillomavirus status and the cervicovaginal microbiome in cervical cancer

HDT Nguyen, TM Le, E Lee, D Lee, Y Choi, J Cho… - Microorganisms, 2023 - mdpi.com
Uterine cervical cancer (CC) is a complex, multistep disease primarily linked to persistent
infection with high-risk human papillomavirus (HR-HPV). However, it is widely …

[HTML][HTML] Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods

GDS Correia, JR Marchesi, DA MacIntyre - Current Opinion in Microbiology, 2023 - Elsevier
Over the last two decades, sequencing-based methods have revolutionised our
understanding of niche-specific microbial complexity. In the lower female reproductive tract …

Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain

N Jimenez, T Norton, G Diadala, E Bell, M Valenti… - BMC medicine, 2024 - Springer
Background Chronic pelvic pain (CPP) is a multifactorial syndrome that can substantially
affect a patient's quality of life. Endometriosis is one cause of CPP, and alterations of the …

New perspectives into the vaginal microbiome with systems biology

CY Lee, LR Dillard, JA Papin, KB Arnold - Trends in Microbiology, 2023 - cell.com
The vaginal microbiome (VMB) is critical to female reproductive health; however, the
mechanisms associated with optimal and non-optimal states remain poorly understood due …

[HTML][HTML] Cervicovaginal microbiome, high-risk HPV infection and cervical cancer: Mechanisms and therapeutic potential

R Huang, Z Liu, T Sun, L Zhu - Microbiological Research, 2024 - Elsevier
The microbiota in the female genital tract is an intricate assembly of diverse aerobic,
anaerobic, and microaerophilic microorganisms, which share the space within the …

Disturbances of vaginal microbiome composition in human papillomavirus infection and cervical carcinogenesis: A qualitative systematic review

M Wu, H Li, H Yu, Y Yan, C Wang, F Teng, A Fan… - Frontiers in …, 2022 - frontiersin.org
Background Emerging evidence has demonstrated a close association between
perturbations in vaginal microbiota composition in women and human papillomavirus (HPV) …