Calcium-dependent exocytosis of synaptic vesicles mediates the release of
neurotransmitters. Important proteins in this process have been identified such as the …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …

Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-
dependent cysteine protease core. These are not degradative enzymes, but instead carry …

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs
are constitutively active, so a major focus has been to identify fusion clamps that regulate …

Isoforms of a gene may contribute to diverse biological functions. In the cochlea, the
repertoire of alternative isoforms remains unexplored. We integrated single-cell short-read …

Synchronous neurotransmission is triggered when Ca2+ binds to synaptotagmin 1 (Syt1), a
synaptic-vesicle protein that interacts with SNAREs and membranes. We used single …

Calcium ions are ubiquitous signalling molecules in all multicellular organisms, where they
mediate diverse aspects of intracellular and extracellular communication over widely varying …

The high toxicity of the seven serotypes of botulinum neurotoxins (BoNT/A to G), together
with their specificity and reversibility, includes them in the list A of potential bioterrorism …

The synaptic vesicle protein synaptotagmin 1 is thought to convey the calcium signal onto
the core secretory machinery. Its cytosolic portion mainly consists of two C2 domains, which …