The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue
is very limited. Disease or injury that causes destruction or damage to neuronal networks …

Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not
only because of the weak intrinsic ability of adult neurons to activate their growth program …

Soluble oligomers of the amyloid-β (Aβ) peptide are thought to play a key role in the
pathophysiology of Alzheimer's disease (AD). Recently, we reported that synthetic Aβ …

Transplantation of mesenchymal stem cells (MSCs) derived from bone marrow has been
shown to improve functional outcome in spinal cord injury (SCI). We transplanted MSCs …

Functional recovery after adult CNS damage is limited in part by myelin inhibitors of axonal
regrowth. Three molecules, Nogo-A, MAG, and OMgp, are produced by oligodendrocytes …

After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It
has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS …

Background Spinal cord injury (SCI) causes neural disconnection and persistent
neurological deficits, so axon sprouting and plasticity might promote recovery. Soluble Nogo …

The reticulon family is a large and diverse group of membrane-associated proteins found
throughout the eukaryotic kingdom. All of its members contain a carboxy-terminal reticulon …

Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow
improves behavioral function in rat models of spinal cord injury (SCI). However, most studies …

Neuritic abnormalities are a major hallmark of Alzheimer's disease (AD) pathology.
Accumulation of β-amyloid protein (Aβ) in the brain causes changes in neuritic processes in …