Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are
27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA …

Studies using dogs provide an ideal solution to the gap in animal models for natural disease
and translational medicine. This is evidenced by approximately 400 inherited disorders …

Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and
dogs, although the disease occurs in dogs approximately 10 times more frequently than in …

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet
dogs. To define the genomic underpinnings of canine OS, we performed multi-platform …

Background Pulmonary metastasis continues to be the most common cause of death in
osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has …

Osteosarcoma (OSA) is the most common primary bone tumour in dogs. The appendicular
locations are most frequently involved and large to giant breed dogs are commonly affected …

Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to
develop and implement new therapies, patient outcomes have not measurably improved …

Despite recent major clinical breakthroughs in human cancer immunotherapy including the
use of checkpoint inhibitors and engineered T cells, important challenges remain, including …

Osteosarcoma (OS) is the most common primary bone tumor in dogs, accounting for up to
85% of malignancies originating in the skeleton. 1-5 OS is estimated to occur in more than …