Recent advances of organ-on-a-chip in cancer modeling research

X Liu, Q Su, X Zhang, W Yang, J Ning, K Jia, J Xin, H Li… - Biosensors, 2022 - mdpi.com
Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …

Lab-on-a-chip systems for cancer biomarker diagnosis

C Özyurt, İ Uludağ, B İnce, MK Sezgintürk - Journal of Pharmaceutical and …, 2023 - Elsevier
Abstract Lab-on-a-chip (LOC) or micro total analysis system is one of the microfluidic
technologies defined as the adaptation, miniaturization, integration, and automation of …

Recent advances in integrated microfluidics for liquid biopsies and future directions

J Zhuang, L Xia, Z Zou, J Yin, N Lin, Y Mu - Biosensors and Bioelectronics, 2022 - Elsevier
Liquid biopsies have piqued the interest of researchers as a new tumor diagnosis technique
due to their unique benefits of non-invasiveness, sensitivity, and convenience. Recent …

Bio-inspired nanomaterials for micro/nanodevices: a new era in biomedical applications

M Harun-Ur-Rashid, I Jahan, T Foyez, AB Imran - Micromachines, 2023 - mdpi.com
Exploring bio-inspired nanomaterials (BINMs) and incorporating them into
micro/nanodevices represent a significant development in biomedical applications …

Circulating histones to detect and monitor the progression of cancer

DK Tsoneva, MN Ivanov, NV Conev, R Manev… - International journal of …, 2023 - mdpi.com
Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring
method, which could identify cancer-related alterations in nucleosome or histone levels and …

Clinical applications of circulating tumour cells and circulating tumour DNA in non-small cell lung cancer—an update

J Kapeleris, M Ebrahimi Warkiani, A Kulasinghe… - Frontiers in …, 2022 - frontiersin.org
Despite efforts to improve earlier diagnosis of non-small cell lung cancer (NSCLC), most
patients present with advanced stage disease, which is often associated with poor survival …

Exploratory evaluation of EGFR-targeted anti-tumor drugs for lung cancer based on lung-on-a-chip

J Tan, X Sun, J Zhang, H Li, J Kuang, L Xu, X Gao… - Biosensors, 2022 - mdpi.com
In this study, we used three-dimensional (3D) printing to prepare a template of a microfluidic
chip from which a polydimethylsiloxane (PDMS) lung chip was successfully constructed. The …

The utility of ctDNA in lung cancer clinical research and practice: a systematic review and meta-analysis of clinical studies

X Sun, P Abrahamson, N Ballew, L Kalilani… - Cancer …, 2023 - Taylor & Francis
This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of
circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase …

Determination of exosome mitochondrial DNA as a biomarker of renal cancer aggressiveness

E Arance, V Ramírez, A Rubio-Roldan… - Cancers, 2021 - mdpi.com
Simple Summary Components of liquid biopsy are potential non-invasive biomarkers for
monitoring renal cell carcinoma (RCC) status. The aim of our study was to examine …

Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer

GM Stella, S Lettieri, D Piloni, I Ferrarotti, F Perrotta… - Pharmaceuticals, 2023 - mdpi.com
Background and rationale. The therapeutic interventions against lung cancer are currently
based on a fully personalized approach to the disease with considerable improvement of …