The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from
South Asia. The ease of care, year‐round prolific breeding, and transparent, external …

Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite
cells, these normally quiescent cells are induced to proliferate by wound-derived signals …

The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers
graded forward locomotion. How MLR neurons recruit downstream vsx2+(V2a) …

INTRODUCTION In animals, gene regulatory networks specify cell identity in space and
time. Transcription of genes in these networks is modulated by a class of cis-regulatory …

In order to localize the neural circuits involved in generating behaviors, it is necessary to
assign activity onto anatomical maps of the nervous system. Using brain registration across …

Understanding brain-wide neuronal dynamics requires a detailed map of the underlying
circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 …

Sequence-specific nucleases like TALENs and the CRISPR/Cas9 system have greatly
expanded the genome editing possibilities in model organisms such as zebrafish. Both …

Macrophages and neutrophils play important roles during the innate immune response,
phagocytosing invading microbes and delivering antimicrobial compounds to the site of …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …