Identification of neoantigens for individualized therapeutic cancer vaccines
Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
recognized by autologous T cells in the host. As neoepitopes are not subject to central …
Rational combinations of targeted cancer therapies: background, advances and challenges
H Jin, L Wang, R Bernards - Nature Reviews Drug Discovery, 2023 - nature.com
Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …
Ensembl 2023
FJ Martin, MR Amode, A Aneja… - Nucleic acids …, 2023 - academic.oup.com
Abstract Ensembl (https://www. ensembl. org) has produced high-quality genomic resources
for vertebrates and model organisms for more than twenty years. During that time, our …
for vertebrates and model organisms for more than twenty years. During that time, our …
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
Z Yang, C Yan, J Ma, P Peng, X Ren, S Cai, X Shen… - Nature …, 2023 - nature.com
Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
Deep learning in cancer diagnosis, prognosis and treatment selection
Deep learning is a subdiscipline of artificial intelligence that uses a machine learning
technique called artificial neural networks to extract patterns and make predictions from …
technique called artificial neural networks to extract patterns and make predictions from …
Substitution mutational signatures in whole-genome–sequenced cancers in the UK population
A Degasperi, X Zou, T Dias Amarante… - Science, 2022 - science.org
Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses,
revealing mutational signatures, imprints of DNA damage, and repair processes that have …
revealing mutational signatures, imprints of DNA damage, and repair processes that have …
[HTML][HTML] Ordered and deterministic cancer genome evolution after p53 loss
Although p53 inactivation promotes genomic instability and presents a route to malignancy
for more than half of all human cancers,, the patterns through which heterogenous TP53 …
for more than half of all human cancers,, the patterns through which heterogenous TP53 …
Life histories of myeloproliferative neoplasms inferred from phylogenies
N Williams, J Lee, E Mitchell, L Moore, EJ Baxter… - Nature, 2022 - nature.com
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …
The microbiome and human cancer
BACKGROUND Historical accounts linking cancer and microbes date as early as four
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …
millennia ago. After establishment of the germ theory of infectious diseases, clinical research …
The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …