Diarrhea after allogeneic stem cell transplantation: beyond graft-versus-host disease

K Robak, J Zambonelli, J Bilinski… - European Journal of …, 2017 - journals.lww.com
Diarrhea constitutes a frequent and often debilitating complication of allogeneic
hematopoietic cell transplantation (alloHCT). Especially when accompanied by jaundice …

The immunopathogenesis of celiac disease reveals possible therapies beyond the gluten-free diet

CS McAllister, MF Kagnoff - Seminars in immunopathology, 2012 - Springer
Celiac disease is a T cell-mediated autoimmune inflammatory disease of the small intestine
that is activated by gluten. The diagnosis of celiac disease is challenging as patients display …

Epithelial cell dysfunction in coeliac disease

C Escudero-Hernández - International Review of Cell and Molecular …, 2021 - Elsevier
The intestinal epithelium limits host-luminal interactions and maintains gut homeostasis.
Breakdown of the epithelial barrier and villous atrophy are hallmarks of coeliac disease …

[HTML][HTML] The Impact of Cellular Therapies on Gastrointestinal Diseases: Applications and Challenges

MM Zhang, Y Hu, J Xu, L Liu, LL Lv - The Turkish Journal of …, 2023 - ncbi.nlm.nih.gov
Gastrointestinal diseases are highly prevalent, and their burden significantly impacts the
quality of life of affected individuals. Inflammatory and immune-mediated intestinal diseases …

[HTML][HTML] Intestinal stem cells and celiac disease

AC Piscaglia - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
Stem cells (SCs) are the key to tissue genesis and regeneration. Given their central role in
homeostasis, dysfunctions of the SC compartment play a pivotal role in the development of …

Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease

R Ciccocioppo, ME Bernardo, ML Russo… - Journal of pediatric …, 2013 - journals.lww.com
We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who
underwent successful myeloablative allogeneic hematopoietic stem cell transplantation …

Concise review: Cellular therapies: The potential to regenerate and restore tolerance in immune-mediated intestinal diseases

R Ciccocioppo, GC Cangemi, P Kruzliak… - Stem Cells, 2016 - academic.oup.com
Chronic inflammatory enteropathies, including celiac disease, Crohn's disease, and
ulcerative colitis, are lifelong disabling conditions whose cure is still an unmet need, despite …

Cellular therapies for the treatment of immune-mediated GI and liver disease

S Khan, RS Khan, PN Newsome - British medical bulletin, 2020 - academic.oup.com
Introduction Immune-mediated liver and gastrointestinal diseases are chronic conditions that
lack curative treatments. Despite advances in the understanding and treatment of these …

Are stem cells a potential therapeutic tool in coeliac disease?

R Ciccocioppo, GC Cangemi, EA Roselli… - Cellular and Molecular …, 2015 - Springer
Despite the growing understanding of its pathogenesis, the treatment of coeliac disease is
still based on a lifelong gluten-free diet that, although efficacious, is troublesome for affected …

Hematopoietic stem cell transplantation for pediatric autoimmune disease: where we stand and where we need to go

AC Krauss, NR Kamani - Bone Marrow Transplantation, 2009 - nature.com
In children, autoimmune diseases and their therapies cause significant morbidity, especially
in those with severe or refractory disease. The constant development of new …