[HTML][HTML] Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …
of worldwide age-related cognitive decline and dementia. In the absence of effective …
[HTML][HTML] Cellular senescence in brain aging
E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
[HTML][HTML] Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches
Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …
[PDF][PDF] Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential
The increase in life expectancy has boosted the incidence of age-related pathologies
beyond social and economic sustainability. Consequently, there is an urgent need for …
beyond social and economic sustainability. Consequently, there is an urgent need for …
[HTML][HTML] Human trials exploring anti-aging medicines
L Guarente, DA Sinclair, G Kroemer - Cell Metabolism, 2024 - cell.com
Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
[PDF][PDF] Dietary spermidine improves cognitive function
Decreased cognitive performance is a hallmark of brain aging, but the underlying
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …
Polyamines in Parkinson's disease: balancing between neurotoxicity and neuroprotection
S Vrijsen, M Houdou, A Cascalho… - Annual Review of …, 2023 - annualreviews.org
The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …
[HTML][HTML] Mechanisms of spermidine-induced autophagy and geroprotection
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …
recently discovered compounds that extend the healthspan and lifespan of model organisms …
Mnemonic similarity task: A tool for assessing hippocampal integrity
The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …