The role of epigenetics in placental development and the etiology of preeclampsia
C Apicella, CSM Ruano, C Méhats, F Miralles… - International journal of …, 2019 - mdpi.com
In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …
placental development as well as in a prominent disease of placental origin, preeclampsia …
Current approaches and developments in transcript profiling of the human placenta
BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …
molecular marks of rapid development and exposures in utero. The placenta is routinely …
[HTML][HTML] Sperm histone H3 lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction
Objective Parental environmental exposures can strongly influence descendant risks for
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …
adult disease. How paternal obesity changes the sperm chromatin leading to the acquisition …
The clinical heterogeneity of preeclampsia is related to both placental gene expression and placental histopathology
Background Preeclampsia is a life-threatening disorder of pregnancy, demonstrating a high
degree of heterogeneity in clinical features such as presentation, disease severity, and …
degree of heterogeneity in clinical features such as presentation, disease severity, and …
Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology
Background A normally developed placenta is integral to a successful pregnancy.
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy …
Preeclampsia (PE) and intrauterine growth restriction (IUGR) are two common pregnancy …
A review of omics approaches to study preeclampsia
PA Benny, FM Alakwaa, RJ Schlueter, CB Lassiter… - Placenta, 2020 - Elsevier
Preeclampsia is a medical condition affecting 5–10% of pregnancies. It has serious effects
on the health of the pregnant mother and developing fetus. While possible causes of …
on the health of the pregnant mother and developing fetus. While possible causes of …
Large-scale placenta DNA methylation integrated analysis reveals fetal sex-specific differentially methylated CpG sites and regions
SV Andrews, IJ Yang, K Froehlich, T Oskotsky… - Scientific reports, 2022 - nature.com
Although male–female differences in placental structure and function have been observed,
little is understood about their molecular underpinnings. Here, we present a mega-analysis …
little is understood about their molecular underpinnings. Here, we present a mega-analysis …
Insight into the key points of preeclampsia pathophysiology: uterine artery remodeling and the role of microRNAs
K Pankiewicz, A Fijałkowska, T Issat… - International journal of …, 2021 - mdpi.com
Preeclampsia affects about 3–8% of all pregnancies. It represents a complex and
multifaceted syndrome with at least several potential pathways leading to the development …
multifaceted syndrome with at least several potential pathways leading to the development …
Placental ageing in adverse pregnancy outcomes: telomere shortening, cell senescence, and mitochondrial dysfunction
S Manna, C McCarthy… - Oxidative medicine and …, 2019 - Wiley Online Library
Preeclampsia is a multisystemic pregnancy disorder and a major cause of maternal and
neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia …
neonatal morbidity and mortality worldwide. The exact pathophysiology of preeclampsia …
Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome
The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …