A comprehensive, model-based review of vaccine and repeat infection trials for filariasis
CP Morris, H Evans, SE Larsen… - Clinical microbiology …, 2013 - Am Soc Microbiol
Filarial worms cause highly morbid diseases such as elephantiasis and river blindness.
Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of …
Since the 1940s, researchers have conducted vaccine trials in 27 different animal models of …
Lymphatic filariasis vaccine development: neglected for how long?
Introduction Lymphatic filariasis (LF), also known as elephantiasis, has been recognized by
the world health organization and the centers for disease control and prevention as one of …
the world health organization and the centers for disease control and prevention as one of …
Comparison of humoral and cell-mediated immune responses to cationic PLGA microspheres containing recombinant hepatitis B antigen
Presently available marketed alum adsorbed hepatitis B vaccine used for prophylactic
immunization, can effectively elicit humoral immunity but is poor inducer of cell-mediated …
immunization, can effectively elicit humoral immunity but is poor inducer of cell-mediated …
Lymphatic filariasis and visceral leishmaniasis coinfection: A review on their epidemiology, therapeutic, and immune responses
V Kushwaha, S Kaur - Acta Tropica, 2021 - Elsevier
Coinfection is less commonly observed in individuals around the world, yet it is more
common than the single infection. Around 800 million people worldwide are infected with …
common than the single infection. Around 800 million people worldwide are infected with …
Immunization with inflammatory proteome of Brugia malayi adult worm induces a Th1/Th2-immune response and confers protection against the filarial infection
Mastomys coucha and jirds (Meriones unguiculatus) were immunized with four cytokine-
stimulating SDS-PAGE resolved fractions F5 (68–84kDa), F6 (54–68kDa), F10 (38–42kDa) …
stimulating SDS-PAGE resolved fractions F5 (68–84kDa), F6 (54–68kDa), F10 (38–42kDa) …
Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis
S Ziewer, MP Hübner, B Dubben… - PLoS neglected …, 2012 - journals.plos.org
Background Lymphatic filariasis and onchocerciasis are two chronic diseases mediated by
parasitic filarial worms causing long term disability and massive socioeconomic problems …
parasitic filarial worms causing long term disability and massive socioeconomic problems …
Troponin 1 of human filarial parasite Brugia malayi: cDNA cloning, expression, purification, and its immunoprophylactic potential
V Kushwaha, P Tewari, P Mandal, A Tripathi… - Parasitology …, 2019 - Springer
In the search for immunoprophylactics for the control of human lymphatic filariasis, we
recently identified troponin 1 (Tn1) in Brugia malayi adult worms. The present study reports …
recently identified troponin 1 (Tn1) in Brugia malayi adult worms. The present study reports …
Influence of Brugia malayi life stages and BmAFII fraction on experimental Leishmania donovani infection in hamsters
The influence of live Brugia malayi parasites and a Sephadex G-200 fraction of the adult
parasite extract (BmAFII) on the progression of Leishmania donovani infection was studied …
parasite extract (BmAFII) on the progression of Leishmania donovani infection was studied …
Sensitization with anti-inflammatory BmAFI of Brugia malayi allows L3 development in the hostile peritoneal cavity of Mastomys coucha
Filarial parasites survive by inducing tolerance in host but the antigens and mechanisms
involved are not clear. Recently we found that BmAFI, a Sephadex G-200 eluted fraction of …
involved are not clear. Recently we found that BmAFI, a Sephadex G-200 eluted fraction of …
Disorganized muscle protein-1 (DIM-1) of filarial parasite Brugia malayi: cDNA cloning, expression, purification, structural modeling and its potential as vaccine …
We have recently identified disorganized muscle protein-1 (DIM-1) in one of the
proinflammatory fractions of the human filaria Brugia malayi adult worm. The present study …
proinflammatory fractions of the human filaria Brugia malayi adult worm. The present study …