This report presents an overview of how machine learning is rapidly advancing clinical
translational imaging in ways that will aid in the early detection, prediction, and treatment of …

The major therapeutic end points of general anesthesia include hypnosis, amnesia, and
immobility. There is a complex relationship between general anesthesia, responsiveness …

Background Intraoperative burst-suppression is associated with postoperative delirium.
Whether this association is causal remains unclear. Therefore, the authors investigated …

In current anesthesiology practice, anesthesiologists infer the state of unconsciousness
without directly monitoring the brain. Drug-and patient-specific electroencephalographic …

Understanding anesthetic mechanisms with the goal of producing anesthetic states with
limited systemic side effects is a major objective of neuroscience research in …

Abstract Study Objectives Intra-operative electroencephalographic (EEG) monitoring
utilizing the spectrogram allows visualization of children's brain response during anesthesia …

Classifying the patient's depth of anesthesia (LoH) level into a few distinct states may lead to
inappropriate drug administration. To tackle the problem, this paper presents a robust and …

Background Phase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-
channel electroencephalography (EEG) to measure the temporal pattern diversity in the …

BACKGROUND: Electroencephalogram (EEG) discontinuity can occur at high
concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This …

Background Dexmedetomidine is only approved for use in humans as an intravenous
medication. An oral formulation may broaden the use and benefits of dexmedetomidine to …