Polycystic ovary syndrome (PCOS) is the leading endocrine and metabolic disorder in
premenopausal women characterized by hyperandrogenism and abnormal development of …

The epigenome controls all aspect of eukaryotic development as the packaging of DNA
greatly affects gene expression. Epigenetic changes are reversible and do not affect the …

Mitochondrial remodeling during the peri-implantation stage is the hallmark event essential
for normal embryogenesis. Among the changes, enhanced oxidative phosphorylation is …

Epigenetic remodeling and modifications of chromatin structure by DNA methylation and
histone modifications represent central mechanisms for the regulation of neuronal gene …

The possible impact of natural heat stress on animal fertility is currently a major concern for
breeding companies. Here, we aimed to address this concern by determining the effects of …

One-carbon (1C) metabolism consists of an integrated series of metabolic pathways that
include the folate cycle and methionine remethylation and trans-sulfuration pathways. Most …

Clinical and experimental evidences indicate that epigenetic modifications induced by the
prenatal environment are related to metabolic and reproductive derangements in polycystic …

Although embryo implantation is essential for human survival, it remains an enigmatic
biological phenomenon. Following fertilization, the resulting blastocyst must signal its …

Studies in humans and mice have revealed that hair follicle morphogenesis relies on tightly
coordinated ectodermal–mesodermal interactions, involving multiple signals and regulatory …

Bioorthogonal chemistry represents a powerful tool in chemical biology, which shows great
potential in epigenetic modulation. As a proof of concept, the epigenetic modulation model …