Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …

Picornaviruses cover a large family of pathogens that have a major impact on human but
also on veterinary health. Although most infections in man subside mildly or …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

In RNA viruses, a small increase in their mutation rates can be sufficient to exceed their
threshold of viability. Lethal mutagenesis is a therapeutic strategy based on the use of …

Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex
and either the natural substrate CTP or the inhibitor 5-nitrocytidine triphosphate have been …

US9090642B2 - Methods for the preparation of diasteromerically pure phosphoramidate
prodrugs - Google Patents US9090642B2 - Methods for the preparation of diasteromerically pure …

Picornaviridae is one of the largest viral families and is composed of 14 genera, six of which
include human pathogens. The best known picornaviruses are enteroviruses (including …

Enteroviruses (EVs) are common human pathogens that are associated with numerous
disease symptoms in many organ systems of the body. Although EV infections commonly …

ABSTRACT Enterovirus 71 (EV71) has emerged as an important virulent neurotropic
enterovirus in young children. DTriP-22 (4 {4-[(2-bromo-phenyl)-(3-methyl-thiophen-2-yl) …

RNA viruses exhibit increased mutation frequencies relative to other organisms. Recent
work has attempted to exploit this unique feature by increasing the viral mutation frequency …