Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

J Akhtar, AA Khan, Z Ali, R Haider, MS Yar - European journal of medicinal …, 2017 - Elsevier
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Pyridines and Imidazopyridines with medicinal significance

T LS Kishbaugh - Current Topics in Medicinal Chemistry, 2016 - ingentaconnect.com
Pyridine and pyridine-fused ring systems are ubiquitous in medicinal research and
demonstrate such diverse pharmacological benefits as anticonvulsant therapies, treatment …

Synthesis and antiproliferative activity of novel selenoester derivatives

E Domínguez-Álvarez, D Plano, M Font, A Calvo… - European journal of …, 2014 - Elsevier
A series of 31 new selenoesters were synthesized and their cytotoxic activity was evaluated
against a prostate cancer cell line (PC-3). The most active compounds were also tested …

[HTML][HTML] Benzothiazoles from Condensation of o-Aminothiophenoles with Carboxylic Acids and Their Derivatives: A Review

EV García-Báez, II Padilla-Martínez, F Tamay-Cach… - Molecules, 2021 - mdpi.com
Nowadays, organic chemists are interested in the field of heterocyclic chemistry due to its
use in the synthesis of a great variety of biologically active compounds. Heterocyclic …

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles

L Racané, M Cindrić, I Zlatar, T Kezele… - Journal of enzyme …, 2021 - Taylor & Francis
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3, 4, 5,
6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential …

An efficient synthesis of novel di-heterocyclic benzazole derivatives and evaluation of their antiproliferative activities

O Algul, RH Ersan, MA Alagoz, N Duran… - Journal of …, 2021 - Taylor & Francis
A series of unsymmetrical nine di-heterocyclic compounds of benzazole derivatives were
synthesized at one step via cyclization reaction. The compounds evaluated for in vitro …

Antibacterial activity, computational analysis and host toxicity study of thymol-sulfonamide conjugates

SS Swain, SK Paidesetty, RN Padhy - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus
faecalis (VRE) are notorious pathogenic multidrug resistant (MDR) bacteria in both hospital …

New anticancer active and selective phenylene-bisbenzothiazoles: synthesis, antiproliferative evaluation and DNA binding

L Racané, SK Pavelić, R Nhili, S Depauw… - European journal of …, 2013 - Elsevier
Novel amidino-derivatives of phenylene-bisbenzothiazoles were synthesized and tested for
their antiproliferative activity against several human cancer cell lines, as well as DNA …

Head-to-head bisbenzazole derivatives as antiproliferative agents: design, synthesis, in vitro activity, and SAR analysis

RH Ersan, MA Alagoz, T Ertan-Bolelli, N Duran… - Molecular Diversity, 2021 - Springer
In the present work, a series of bisbenzazole derivatives were designed and synthesized as
antiproliferative agents. The antiproliferative activity of these compounds was investigated …