AGE/RAGE in diabetic kidney disease and ageing kidney

XQ Wu, DD Zhang, YN Wang, YQ Tan, XY Yu… - Free Radical Biology …, 2021 - Elsevier
Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease that inevitably
progress to end-stage kidney disease. Intervention strategies such as blood glucose control …

Targeting inflammation in diabetic nephropathy: a tale of hope

JA Moreno, C Gomez-Guerrero, S Mas… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease
(CKD) and end-stage renal disease (ESRD). Beyond the new anti-diabetic drugs that …

The glyoxalase system in age-related diseases: nutritional intervention as anti-ageing strategy

G Aragonès, S Rowan, SG Francisco, EA Whitcomb… - Cells, 2021 - mdpi.com
The glyoxalase system is critical for the detoxification of advanced glycation end-products
(AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of …

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

F Tong, S Liu, B Yan, X Li, S Ruan… - International Journal of …, 2017 - Taylor & Francis
The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle
complex on diabetic nephropathy (DN) by regulating the expression of intercellular …

A promising antifibrotic drug, pyridoxamine attenuates thioacetamide-induced liver fibrosis by combating oxidative stress, advanced glycation end products, and …

AR Alshanwani, H Hagar, S Shaheen… - European Journal of …, 2022 - Elsevier
Liver fibrosis is a common chronic hepatic disease. This study was done to examine the
effect of pyridoxamine against thioacetamide-induced hepatic fibrosis. Animals were divided …

Red onion scales ameliorated streptozotocin-induced diabetes and diabetic nephropathy in Wistar rats in relation to their metabolite fingerprint

TK Abouzed, M del Mar Contreras, KM Sadek… - Diabetes Research and …, 2018 - Elsevier
Aim The present study was designed to investigate the effect of red onion scales extract
(ROS) against diabetic nephropathy, in relation to its metabolic profiling. Methods Four …

Preparation of exenatide-loaded linear poly(ethylene glycol)-brush poly(l-lysine) block copolymer: potential implications on diabetic nephropathy

F Tong - International journal of nanomedicine, 2017 - Taylor & Francis
The poly (ethylene glycol)-b-brush poly (l-lysine) polymer (PEG-b-(PELG50-g-PLL3)) was
synthesized and evaluated as a nanocarrier for prolonging delivery of exenatide through the …

Protective effects of pyridoxamine supplementation in the early stages of diet‐induced kidney dysfunction

F Chiazza, AS Cento, D Collotta, D Nigro… - BioMed research …, 2017 - Wiley Online Library
Pyridoxamine, a structural analog of vitamin B6 that exerts antiglycative effects, has been
proposed as supplementary approach in patients with initial diabetic nephropathy. However …

[HTML][HTML] Metabolomics of acid whey derived from Greek yogurt

MM Allen, OA Pike, JD Kenealey, ML Dunn - Journal of Dairy Science, 2021 - Elsevier
Acid whey, a byproduct of Greek yogurt production, has little commercial value due to its low
protein content and is also environmentally harmful when disposed of as waste. However …

[HTML][HTML] Pyridoxamine treatment of HK-2 human proximal tubular epithelial cells reduces oxidative stress and the inhibition of autophagy induced by high glucose …

Y Wang, Y Li, Z Yang, Z Wang, J Chang… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Background Diabetic nephropathy is a predominant cause of renal failure, which is an
important chronic complication of diabetes. Pyridoxamine (PM) has been reported to protect …