The development of the neuroendocrine hypothalamus has been studied using a variety of
neuroanatomical and molecular techniques. Here, the major findings that mold our …

Human organoids stand at the forefront of basic and translational research, providing
experimentally tractable systems to study human development and disease. These stem cell …

The hypothalamus is a central regulator of many innate behaviors essential for survival, but
the molecular mechanisms controlling hypothalamic patterning and cell fate specification …

Hypothalamic tanycytes, radial glial cells that share many features with neuronal
progenitors, can generate small numbers of neurons in the postnatal hypothalamus, but the …

Social isolation is considered a stressful situation that results in increased physiological
reactivity to novel stimuli, altered behaviour, and impaired brain function. Here, we …

The hypothalamus regulates many innate behaviors, but its development remains poorly
understood. Here, we used single-cell RNA sequencing (RNA-seq) and hybridization chain …

The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its
fundamental role, the cells and signalling pathways that specify this unique region of the …

Holoprosencephaly is a pathology of forebrain development characterized by high
phenotypic heterogeneity. The disease presents with various clinical manifestations at the …

Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout
vertebrate neural development. Wnt/β-catenin signaling is important for mammalian …

The inner ear is derived from the otic placode, one of the numerous cranial sensory
placodes that emerges from the pre-placodal ectoderm (PPE) along its anterior-posterior …