With the rapid development of microfluidic platforms in high-throughput single-cell culturing,
laborious operation to manipulate massive budding yeast cells (Saccharomyces cerevisiae) …

Adult stem cells (SCs) represent the regenerative capacity of organisms throughout their
lifespan. The maintenance of robust SC populations capable of renewing organs and …

Introduction: Essential genes are essential for the survival of various species. These genes
are a family linked to critical cellular activities for species survival. These genes are coded …

Aging is a complex phenomenon of functional decay in a biological organism. Although the
effects of aging are readily recognizable in a wide range of organisms, the cause (s) of aging …

Microfluidic-based assays have become effective high-throughput approaches to examining
replicative aging of budding yeast cells. Deep learning may offer an efficient way to analyze …

Microfluidic systems have been widely utilized in high-throughput biology analysis, but the
difficulties in liquid manipulation and cell cultivation limit its application. This work has …

We proposed a novel interaction potential landscape approach to map the systems-level
profile changes of gene networks during replicative aging in Saccharomyces cerevisiae …

Based on the study of cellular aging using the single-cell model organism of budding yeast
and corroborated by other studies, we propose the Emergent Aging Model (EAM). EAM …

Background/study context: Empirical lifespan data sets are often studied with the best-fitted
mathematical model for aging. Here, we studied how experimental noises can influence the …

Time-lapse microscopy is an effective research tool to monitor cell behavior and cell
divisions. Recent advances in microfluidics have accelerated the adoption of time-lapse …