Importance Alcohol use disorder affects more than 28.3 million people in the United States
and is associated with increased rates of morbidity and mortality. Objective To compare …

Importance Alcohol use disorders cause substantial morbidity and early mortality yet remain
greatly undertreated. Medications are considerably underused. Objective To conduct a …

The goal of this guideline1 is to improve the quality of care and treatment outcomes for
patients with alcohol use disorder (AUD), as defined by DSM-5 (American Psychiatric …

Aims Although debates over the efficacy of oral naltrexone and acamprosate in treating
alcohol use disorders tend to focus on their global efficacy relative to placebo or their …

Background Alcohol dependence belongs to the globally leading health risk factors.
Therapeutic success of psychosocial programs for relapse prevention is moderate and could …

Aims To ascertain the efficacy and safety of naltrexone and acamprosate in the treatment of
alcohol dependence. Methods Systematic review of the literature (1990–2002) and meta …

Excessive consumption of alcohol is among the leading causes of preventable death
worldwide. Although ethanol modulates a variety of molecular targets, including several …

Background: Alcohol use disorder (AUD) and its associated consequences remain
significant public health concerns. Given that AUD represents a spectrum of severity …

The purpose of this article is to review current empirical research on the effectiveness of
drug treatment programs, particularly those for prisoners, parolees, and probationers. The …

Many trials of naltrexone have been carried out in alcohol-dependent patients. This paper is
aimed to systematically review its benefits, adverse effects, and discontinuation of treatment …