Electrochemistry at the interface between two immiscible electrolyte solutions (ITIES) gains
more and more interest due to its wide range of applications. The present review …

In this review, we first examine the contextual background of structure–pharmacokinetic
relationships. Some concepts in drug disposition are briefly recalled, and inherent difficulties …

For developing a promising sensor, sensitivity and selectivity are the most critical key issues.
In efforts to develop novel sensor materials, various types of modifiers such as carbon …

Predicting blood− brain barrier (BBB) permeation remains a challenge in drug design. Since
it is impossible to determine experimentally the BBB partitioning of large numbers of …

Consensus group on new-generation antihistamines (CONGA): present status and
recommendations Page 1 Consensus group on new-generation antihistamines (CONGA) …

Assessment of proarrhythmic toxicity of newly developed drugs attracts significant attention
from drug developers and regulatory agencies. Although no guidelines exist for such …

Abstract Evaluation of a multiplexed capillary electrophoresis (CE) method for pK a
measurements of organic compounds, including low solubility compounds, is presented …

Competition experiments with [3H] mepyramine showed that cetirizine and its enantiomers,
levocetirizine and (S)-cetirizine, bound with high affinity and stereoselectivity to human H1 …

Absorption, distribution, metabolism and excretion of desloratadine, fexofenadine,
levocetirizine, and mizolastine in humans have been compared. The time required to reach …

BACKGROUND: Levocetirizine is the active enantiomer of cetirizine, a potent drug with little
metabolism widely used for allergic rhinitis and urticaria. OBJECTIVE: This study compares …