Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Covering: up to 2015 Over the centuries, microbial secondary metabolites have played a
central role in the treatment of human diseases and have revolutionised the pharmaceutical …

Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …

Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …

Epothilones are secondary metabolites produced by Sorangium cellulosum with powerful
antiproliferative activity against tumor cells by stabilizing their microtubule arrays, arresting …

Microorganisms are ubiquitous on earth, often forming complex microbial communities in
numerous different habitats. Most of these organisms cannot be readily cultivated in the …

Synthetic biology techniques coupled with heterologous secondary metabolite production
offer opportunities for the discovery and optimisation of natural products. Here we developed …

Cholesterol was first found in gallstones as an animal sterol; hence it is called cholesterol.
Cholesterol oxidase is the chief enzyme in the process of cholesterol degradation. Its role is …

Corallopyronins (COR) are α-pyrone antibiotics from myxobacteria representing highly
promising lead structures for the development of antibacterial therapeutic agents. Their …

Heterologous expression has become a powerful tool for studying microbial biosynthetic
gene clusters (BGCs). Here, we extend the transformation-associated recombination cloning …