The development of mature blood cells from haematopoietic stem cells has long served as a
model for stem-cell research, with the haematopoietic differentiation tree being widely used …

Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Haematopoiesis, the process of mature blood and immune cell production, is functionally
organized as a hierarchy, with self-renewing haematopoietic stem cells and multipotent …

Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis.
In the past decade, the genomics revolution has ushered in powerful new methods for …

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers
of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic …

Abstract Analysis of the human hematopoietic progenitor compartment is being transformed
by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by …

Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in
individuals with cancer; however, such factors have not yet been identified. Here we show …

Aging became a priority in medicine due to the rapid increase of elderly population and age-
related diseases in the Western countries. Nine hallmarks have been identified based on …

Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …

Megakaryocytic-erythroid progenitors (MEPs) give rise to the cells that produce red blood
cells and platelets. Although the mechanisms underlying megakaryocytic (MK) and erythroid …