The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour
tissues are of interest to many cancer researchers. Micro-engineering approaches and …

Tumor cells have the ability to induce platelet activation and aggregation. This has been
documented to be involved in tumor progression in several types of cancers, such as lung …

Cancer is a disease associated with complex pathology and one of the most prevalent and
leading reasons for mortality in the world. Current chemotherapy has challenges with …

Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …

Proteases are enzymes that hydrolyze peptide bonds in proteins and peptides; thus, they
control virtually all biological processes. Our understanding of protease function has …

Gastrointestinal cancers are a leading cause of cancer morbidity and mortality worldwide
with 4.2 million new cases and 3.2 million deaths estimated in 2020. Despite the advances …

Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago,
several roles for proteases in cancer progression have been established. About half of the …

The potential of designing irreversible alkyne-based inhibitors of cysteine cathepsins by
isoelectronic replacement in reversibly acting potent peptide nitriles was explored. The …

Limited proteolysis of thrombospondins is a powerful mechanism to ensure dynamic tuning
of their activities in the extracellular space. Thrombospondins are multifunctional …

Purpose: Small molecule drug conjugates (SMDC) are modular anticancer prodrugs that
include a tumor-targeting small organic ligand, a cleavable linker, and a potent cytotoxic …