Multiple roles of APC and its therapeutic implications in colorectal cancer
Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …
Prebiotics‐encapsulated probiotic spores regulate gut microbiota and suppress colon cancer
While microbial‐based therapy has been considered as an effective strategy for treating
diseases such as colon cancer, its safety remains the biggest challenge. Here, probiotics …
diseases such as colon cancer, its safety remains the biggest challenge. Here, probiotics …
The NF-κB signaling pathway, the microbiota, and gastrointestinal tumorigenesis: recent advances
Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC),
represent a major global health burden. A large population of microorganisms residing in …
represent a major global health burden. A large population of microorganisms residing in …
Accumulation of 8, 9-unsaturated sterols drives oligodendrocyte formation and remyelination
Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem
cell population in the central nervous system (CNS) and the principal source of new …
cell population in the central nervous system (CNS) and the principal source of new …
Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives
Colorectal cancer (CRC) is one of the most common forms of solid tumors in the world with
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …
high rates of mortality and morbidity. Most cases of CRCs are initiated by inactivating …
The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer
Therapeutic targeting of KRAS-mutant colorectal cancer (CRC) is an unmet need. Here, we
show that Proprotein Convertase Subtilisin/Kexin type 9 (PSCK9) promotes APC/KRAS …
show that Proprotein Convertase Subtilisin/Kexin type 9 (PSCK9) promotes APC/KRAS …
Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
E Saunier, S Antonio, A Regazzetti, N Auzeil… - Scientific reports, 2017 - nature.com
Resveratrol (RES), a polyphenol found in natural foods, displays anti-oxidant, anti-
inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in …
inflammatory and anti-proliferative properties potentially beneficial in cancers, in particular in …
Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin
Although the role of the Wnt pathway in colon carcinogenesis has been described
previously, it has been recently demonstrated that Wnt signaling originates from highly …
previously, it has been recently demonstrated that Wnt signaling originates from highly …
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1
JH Cao, CH Cao, JL Lin, SY Li, LJ He, K Han, JW Chen… - Cell Reports, 2024 - cell.com
Deficiency of DNA repair pathways drives the development of colorectal cancer. However,
the role of the base excision repair (BER) pathway in colorectal cancer initiation remains …
the role of the base excision repair (BER) pathway in colorectal cancer initiation remains …