The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Strong adherence to a Mediterranean diet is associated with improved cognitive function
and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources …

Mild deficits in mitochondrial function have been shown to increase lifespan in multiple
species including worms, flies and mice. Here, we study three C. elegans mitochondrial …

Background The mitochondrial unfolded protein response (mitoUPR) is a stress response
pathway activated by disruption of proteostasis in the mitochondria. This pathway has been …

While the pathogenesis of Parkinson's disease (PD) is incompletely understood,
mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we …

Oxidative stress and cytotoxic damage induced by amyloid beta (Aβ) have been considered
pivotal in the pathogenesis of Alzheimer's disease (AD) and may represent a target for …

While mitochondrial function is essential for life in all multicellular organisms, a mild
impairment of mitochondrial function can extend longevity in model organisms. By …

Mutations affecting components of the mitochondrial electron transport chain have been
shown to increase lifespan in multiple species including the worm Caenorhabditis elegans …

Oxidative stress has been proposed to be one of the main causes of aging and has been
implicated in the pathogenesis of many diseases. Sensitivity to oxidative stress can be …

Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat
expansions within the coding region of disease-causing genes. PolyQ-expanded proteins …