The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Beyond the brain: peripheral interactions after traumatic brain injury

SJ McDonald, JM Sharkey, M Sun… - Journal of …, 2020 - liebertpub.com
Traumatic brain injury (TBI) is a leading cause of death and disability, and there are currently
no pharmacological treatments known to improve patient outcomes. Unquestionably …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …

Inflammation in traumatic brain injury: roles for toxic A1 astrocytes and microglial–astrocytic crosstalk

DPQ Clark, VM Perreau, SR Shultz, RD Brady… - Neurochemical …, 2019 - Springer
Traumatic brain injury triggers neuroinflammation that may contribute to progressive
neurodegeneration. We investigated patterns of recruitment of astrocytes and microglia to …

Effects of neurological disorders on bone health

RR Kelly, SJ Sidles, AC LaRue - Frontiers in psychology, 2020 - frontiersin.org
Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

SJ McDonald, M Sun, DV Agoston… - Journal of …, 2016 - Springer
Background Traumatic injuries are physical insults to the body that are prevalent worldwide.
Many individuals involved in accidents suffer injuries affecting a number of extremities and …

Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Longitudinal analyses of the reciprocity of depression and anxiety after traumatic brain injury and its clinical implications

B Wang, M Zeldovich, K Rauen, YJ Wu, A Covic… - Journal of clinical …, 2021 - mdpi.com
Depression and anxiety are common following traumatic brain injury (TBI). Understanding
their prevalence and interplay within the first year after TBI with differing severities may …

Fibrinogen and neuroinflammation during traumatic brain injury

N Sulimai, D Lominadze - Molecular neurobiology, 2020 - Springer
Many neurodegenerative diseases such as Alzheimer's disease (AD), multiple sclerosis,
and traumatic brain injury (TBI) are associated with systemic inflammation. Inflammation …