[HTML][HTML] Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
[HTML][HTML] Quinolones: mechanism, lethality and their contributions to antibiotic resistance
NG Bush, I Diez-Santos, LR Abbott, A Maxwell - Molecules, 2020 - mdpi.com
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …
They have enjoyed over 30 years of clinical usage and become essential tools in the …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
M Nassal - Gut, 2015 - gut.bmj.com
At least 250 million people worldwide are chronically infected with HBV, a small
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
hepatotropic DNA virus that replicates through reverse transcription. Chronic infection …
DNA–protein crosslinks and their resolution
P Weickert, J Stingele - Annual Review of Biochemistry, 2022 - annualreviews.org
Covalent DNA–protein crosslinks (DPCs) are pervasive DNA lesions that interfere with
essential chromatin processes such as transcription or replication. This review strives to …
essential chromatin processes such as transcription or replication. This review strives to …
[HTML][HTML] Replication-coupled DNA repair
D Cortez - Molecular cell, 2019 - cell.com
The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …
However, it can make errors, especially when the template DNA is damaged. In these cases …
Mechanisms of DNA–protein crosslink repair
Covalent DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
and other proteins with DNA are highly toxic DNA lesions. Of note, chemical agents that …
Coordination of DNA single strand break repair
R Abbotts, DM Wilson III - Free Radical Biology and Medicine, 2017 - Elsevier
The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …
changes are programmed, such as the formation of DNA double strand breaks during …
[HTML][HTML] Mechanism and regulation of DNA-protein crosslink repair by the DNA-dependent metalloprotease SPRTN
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential
chromatin transactions, such as replication and transcription. Little was known about DPC …
chromatin transactions, such as replication and transcription. Little was known about DPC …