Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Coordination compounds on account of distinctive features of metal ions that include
variable oxidation states, diverse range of geometries and coordination numbers …

All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …

The tumor microenvironment includes a complicated network of physiological gradients
contributing to plasticity of tumor cells and heterogeneity of tumor tissue. Hypoxia is a key …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Acidic tissue microenvironment contributes to tumor progression via multiple effects
including the activation of angiogenic factors and proteases, reduced cell-cell adhesion …

Background: Most solid tumours contain regions of sub-optimal oxygen concentration
(hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and represent the most …

Cancer cells rely on angiogenesis to fulfil their need for oxygen and nutrients; hence, agents
targeting angiogenic pathways and mediators have been investigated as potential cancer …

We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging
of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two …