Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and
inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an …

The top-down approach to proteomics offers compelling advantages due to the potential to
provide complete characterization of protein sequence and post-translational modifications …

A common key regulator of oncogenic signaling pathways in multiple tumor types is the
unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and …

Pin1 is the only known peptidyl-prolyl cis–trans isomerase (PPIase) that specifically
recognizes and isomerizes the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) …

Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …

Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …

Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling
molecules and whose deregulation contributes to disease notably cancer. However, since …

Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-
binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans …