The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35
years. Over that time span, 1H imaging flourished and was adopted worldwide with an …

A pulse‐sequence strategy was developed for generating regional maps of alveolar oxygen
partial pressure (pO2) in a single 6‐sec breath hold, for use in human subjects with impaired …

Hyperpolarized noble gases (HNGs), polarized to approximately 50% or higher, have led to
major advances in magnetic resonance (MR) imaging of porous structures and air-filled …

Objective The purpose of this work was to develop a rapid 3-D, variable flip angle (VFA)
method for measurement of hyperpolarized 3 He T 1 which accounts for the effects of …

Reliable, noninvasive, and high‐resolution imaging of alveolar partial pressure of oxygen
(pAO2) is a potentially valuable tool in the early diagnosis of pulmonary diseases. Several …

Hyperpolarized noble gas (HNG) magnetic resonance (MR) imaging is a very promising
noninvasive tool for the investigation of animal models of lung disease, particularly to follow …

Abstract Hyperpolarized 3He (HP 3He) MRI shows promise to assess structural and
functional pulmonary parameters in a sensitive, regional, and noninvasive way. Structural …

The purpose of this study was to evaluate whether regional alveolar oxygen tension (PAO2)
vertical gradients imaged with hyperpolarized 3He can identify smoking‐induced pulmonary …